NASA 및 National Academy of Sciences에서 있었던 짱 먹어주는 과학계의 선배님들의(Distinguished Leaders in Science) 중요한 강의영상 3편
광우병, 인간의 신경 지체병, 기기묘묘한 효모....이 들의 공통점은 잘못결합된 단백질(misfolded proteins)이다. 이 찌질이 단백질들이 전염되면 바로 광우병이 되는 거다.
효모를 통해 이러한 전염 프로세스가 관찰됨으로써 치료의 전기를 마련할 수 있다곤 하는데.....
What do "mad cows", people with neurodegenerative diseases and an unusual type of inheritance in yeast have in common? They are all experiencing the consequences of misfolded proteins. When misfolded proteins persist the consequences can be deadly, leading to such devastating diseases as Alzheimer's Disease. And, when passed from one individual to another, misfolded proteins produce infectious neurodegenerative diseases, like Mad Cow disease. Studies on a similar process in yeast cells have revealed beyond a reasonable doubt, a new protein-based mechanism of heredity in this organism. The process of protein misfolding in yeast provides an excellent model for understanding misfolded proteins in humans and accelerates the rate at which we can probe the nature of disease processes and test new therapeutic strategies.
Dr. Susan Lindquist, The Albert D. Lasker Professor of Medical Science, Department of Molecular Genetics and Cell Biology, University of Chicago; investigator, Howard Hughes Medical Institute